Troubleshooting Process Chart
– Probable Instrument Fault
– Correct / Change Set-up & Re-run Analysis
– Probable Methodology Fault
– Leak in System – Pump Fault
– Detector Fault or Injector Fault
– Pump Fault or Column Compartment Fault
– Autosampler Fault
– Improve Method
– High Back Pressure Issues
– Run a Known Method on the System
– Look for Differences Between Systems
– Probable Instrument Fault
– Correct / Change Set-up & Re-run Analysis
– Probable Methodology Fault
– Leak in System – Pump Fault
– Detector Fault or Injector Fault
– Pump Fault or Column Compartment Fault
– Autosampler Fault
– Improve Method
– High Back Pressure Issues
– Run a Known Method on the System
– Look for Differences Between Systems
Step 1 – Do Nothing!
This is your chance to assess the system as it was set up – don’t destroy the evidence.- Are vials in the correct position?
- Is the mobile phase correct and on the correct lines?
- Error messages on the system?
- Is the correct column on the system? (Is it connected correctly?)
- Is there evidence of a leak?


