Ref: st4866


st4866 Xevo TQ MS LC-MS/MS from Waters

This Waters Xevo™ TQD MS system incorporates ScanWave™ collision cell technology, for enhanced spectral LC-MS/MS data acquisition.

Key Points

Unlike conventional tandem quadrupole MS, the Xevo TQ MS is designed not only to provide the very best quantitative data, but also to provide you with superior spectral info, offering you versatility and adaptability for a range of applications: bioanalysis, ADME screening, food safety, environmental monitoring, forensic, and more.


  • Automated system set up and system checks for simple access.
  • Automated instrument optimization and quantitative method development tools for ease-of-use.
  • The latest innovations in high efficiency, robust, easy-to-use ZSpray™ atmospheric pressure ion source technology.
  • Unique, innovative T-Wave™ and ScanWave enabled collision cell technology.
  • Versatile range of ionization options, including multi-mode ionization capability in a single run.
  • Footprint that sits easily on your laboratory benchtop.
  • Dedicated application managers for your specialized analytical requirements.

See what Waters say here >>

XEVO TQ MS Performance Spec

Ion source transfer optics: High efficiency hexapole ion guide.
Mass analyzer: Two high resolution quadrupole analyzers (MS1/MS2), plus pre-filters to maximize resolution and transmission while preventing contamination of the main analyzers.
Collision cell: T-Wave enabled for optimal MS/MS performance at high data acquisition rates; ScanWave enabled for enhanced MS/MS spectral performance (product ion scanning); Software programmable gas control.

Detector: Low noise, off axis, long life photomultiplier detector; Digital dynamic range up to 4 x 106.

Vacuum system: Two air-cooled vacuum turbomolecular pumps evacuating the source and analyzer; One rotary backing pump.

Acquisition modes: Full scan, MS Product ion scan (ScanWave enhanced), Precursor ion scan, Constant neutral loss, Selected ion recording (SIR),Multiple reaction monitoring (MRM).

Survey scan modes: Full scan MS triggered product ion scan, Precursor ion scan triggered product ion scan, Constant neutral loss triggered product ion scan.

Quan Qual mode: MRM triggered ScanWave enhanced product ion spectral acquisition.

Mass range: 2 to 2048 m/z.

Scan speed: Up to 10,000 Da/s, Examples of achievable acquisition rates: 10 scans per second (m/z 100 to 1000), 20 scans per second (m/z 50 to 500).

Mass stability: Mass drift is less than 0.1 amu over a 24 hour period.

Linearity of response: The linearity of response relative to sample concentration, for a specified compound, is five orders of magnitude from the limit of detection.

Polarity switching time: 20 ms to switch between positive and negative ion modes.

MS to MS/MS switching time: 5 ms.

Inter-channel cross talk: The inter-channel cross talk between two MRM transitions, acquired using an MRM dwell time of 10 ms and an inter-channel delay time of 10 ms, will be less than 0.02%.

Number of MRM channels: Up to 16,384 MRM channels (512 functions, 32 channels per function) can be monitored in a single acquisition. Up to 1024 MRM channels when operating in GLP/secure mode (32 functions, 32 channels per function).

Mass resolution: Automatically adjusted (IntelliStart) to desired resolution; (0.40 Da, 0.75 Da or 1.00 Da FWHM).

MRM sensitivity (ESI+): A 50 fg on-column injection of reserpine will give a chromatographic signal-to-noise greater than 500:1 (Gradient separation, LC mobile phase flow rate of 0.8 mL/min, MRM transition m/z 609 > 195).

MRM sensitivity (ESI-): A1 pg on-column injection will give a chromatographic signal-to-noise greater than 1,000:1 (Gradient separation, LC mobile phase flow rate of 0.8 mL/min, MRM transition m/z 321 > 152).

See Waters full specification here >>

System Specification

  • Waters Xevo TQ MS LC-MS/MS with ESI Probe
  • Waters Acquity Classic or H-Class Option:
    • Classic: Waters Acquity Binary Solvent Manager (BSM) + Waters Acquity Sample Manager (SM)
    • H-Class: Waters Acquity Class FTN Sample Manager (FTN-SM) + Waters Acquity (QSM)
  • Waters Acquity Column Manager (CM)
  • Waters Acquity Diode Array Detector (PDA)
  • Waters Acquity Bottle Manager
  • Roughing Pump
  • Windows 7 PC with MassLynx 4.1
  • New Samsung Printer
  • Installation & warranty (as denoted above)
  • Option of a Waters Acquity Sample Organiser (SO) - please enquire

* PC Provided with MassLynx software installed. Note: we are unable to transfer licences therefore software licence purchase may be required from the manufacturer.

Please enquire for full consultation using the form below.


  • System - specification as outlined in the main description
  • Sample testing - supply your compound(s) and our method development expert will provide the results for instrument assessment
  • Demonstration of capability at our lab in Kent, UK
  • Operational Data, Performance Data
  • Full service report
  • System Installation by our in-house MS Engineer (enquire if outside the UK)

Optional Extras

  • Water re-circulator
  • Syringe pump - New or reconditioned
  • Nitrogen Generator - New or reconditioned
  • Air Purifier - from CLAIND
  • Air Compressor - from CLAIND
  • Maintenance Agreements / Calibration - As the UK's biggest independent service provider of LC/GC instrumentation, we offer 4 levels of cover. Details here...
  • On-site Training - Both system overview and software familiarisation
  • Extended Warranty - we know the quality of our workmanship and hold stock of spare parts, so please enquire if you require a longer warranty period.
  • Method Development - Our in-house method development specialist has had over 40 years experience in developing methods for one of the world's largest multi-nationals. Please enquire if you require assistance in developing your methods


Jaytee Biosciences Ltd provide a 12 month on-site warranty (UK), effective from the date of installation.

Note: Our warranty terms quoted for this system apply to mainland UK customers. For clients outside of this locale, please enquire at point of sale.

All warranty repairs will be attended on-site however Jaytee Biosciences reserve the right to return the instrument to base for further troubleshooting if required.


  • Capillaries
  • Tubing
  • Vacuum Pump Oil
  • Exhaust Filters
  • Air Filters
  • PCs and Monitors
  • LC/GC Column Fittings
  • Electron Multipliers

Any other parts where cause of failure can be traced to customer error, neglect or accidental damage.

If you have any further queries or questions regarding warranty, please do not hesitate to contact us below.