Troubleshooting Process Chart
– Probable Instrument Fault
– Correct / Change Set-up & Re-run Analysis
– Probable Methodology Fault
– Leak in System – Pump Fault
– Detector Fault or Injector Fault
– Pump Fault or Column Compartment Fault
– Autosampler Fault
– Improve Method
– High Back Pressure Issues
– Run a Known Method on the System
– Look for Differences Between Systems
– Probable Instrument Fault
– Correct / Change Set-up & Re-run Analysis
– Probable Methodology Fault
– Leak in System – Pump Fault
– Detector Fault or Injector Fault
– Pump Fault or Column Compartment Fault
– Autosampler Fault
– Improve Method
– High Back Pressure Issues
– Run a Known Method on the System
– Look for Differences Between Systems
Look for Differences Between Systems
We mean:- Is it the same make?
- Is it the same model (exactly)?
- Has it got the same configuration?
- If one has a quaternary and one has a binary pump, the gradient profile may be different as they use low and high pressure mixing respectively.
- DAD vs VWD – both use UV detection but sensitivity will be different.
- Syringe vs Metering Drive
- Data capture rate setting on software.
- Tubing connecting components can be a crucial part of the system.
