Troubleshooting Process Chart
– Probable Instrument Fault
– Correct / Change Set-up & Re-run Analysis
– Probable Methodology Fault
– Leak in System – Pump Fault
– Detector Fault or Injector Fault
– Pump Fault or Column Compartment Fault
– Autosampler Fault
– Improve Method
– High Back Pressure Issues
– Run a Known Method on the System
– Look for Differences Between Systems
– Probable Instrument Fault
– Correct / Change Set-up & Re-run Analysis
– Probable Methodology Fault
– Leak in System – Pump Fault
– Detector Fault or Injector Fault
– Pump Fault or Column Compartment Fault
– Autosampler Fault
– Improve Method
– High Back Pressure Issues
– Run a Known Method on the System
– Look for Differences Between Systems
Step 4 -Question the instrument
Are there any indications that the instrument is not working correctly?- Look for tell tale signs (buffer deposits around the pump head)
- Check the system logs to determine areas of poor performance (eg. lamp hours)
- Does the analytical data indicate the system is repeatable? (most systems should achieve area and retention time epeatability <1% RSD)
- What does the baseline look like?
- Investigation tests.
- Run reproducibility injections using known method, column etc.
- Is the pressure normal?
