Step 4 >>

Step 3 – Question the methodology

If everything appears to have been run & prepared correctly – it’s time to separate science from engineering (i.e. method from instrument):

  • Is there evidence that the chemistry is correct (i.e. method validation)?
  • Is the problem isolated to a single instrument / configuration of instrument?
  • If its routine analysis, is the analysis failing on more than one system?
  • Has the method been adjusted / tweaked?
  • Has the analysis worked on this instrument before?
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